Autonomous AI-Driven Clinical Decision System Using Reinforcement Learning and Real-Time Patient Feedback

Authors

  • Geeta Sandhu
  • Karthik Dhillon
  • Deepak Menon
  • Tanvi Shah

DOI:

https://doi.org/10.5281/ijurd.v2i1.29

Keywords:

Cardiovascular Disease, CNN-LSTM, Hybrid Model, Time Series, Healthcare Prediction, Deep Learning

Abstract

The increasing complexity of clinical decision-making requires intelligent systems capable of adapting to dynamic patient conditions. This paper presents an Autonomous AI-Driven Clinical Decision System that leverages reinforcement learning and real-time patient feedback to optimize treatment strategies. The proposed framework models clinical decision-making as a sequential process, where an intelligent agent learns optimal treatment policies by interacting with patient data and outcomes. Reinforcement learning techniques, including deep Q-networks and policy optimization methods, are employed to handle complex and uncertain healthcare environments. The system continuously updates its knowledge based on real-time patient responses, enabling personalized and adaptive treatment recommendations. Integration with electronic health records and wearable devices allows continuous monitoring and feedback-driven learning. Additionally, safety constraints and explainability mechanisms are incorporated to ensure clinical reliability and trust. Experimental results demonstrate that the proposed approach improves treatment outcomes and decision accuracy compared to static models. Integration with prior research in healthcare analytics further enhances system robustness and generalization. The study highlights the potential of autonomous AI systems in transforming healthcare into a proactive and adaptive decision-making ecosystem.

Author Biographies

Geeta Sandhu

Computer Science and Engineering, IIMT College of Engineering, Greater Noida

Karthik Dhillon

Electronics and Communication Engineering, Jagan Institute of Management Studies, Delhi NCR

Deepak Menon

Artificial Intelligence and Machine Learning, HMR Institute of Technology and Management, Delhi

Tanvi Shah

Biomedical Engineering, Eternal University, Baru Sahib

References

Aman, & Chhillar, R. S. (2021). Analyzing predictive algorithms in data mining for cardiovascular disease using WEKA tool. International Journal of Advanced Computer Science and Applications, 12(8), 144–150.

Aman, & Chhillar, R. S. (2022). Analyzing three predictive algorithms for diabetes mellitus against the Pima Indians dataset. ECS Transactions, 107(1), 2697.

Aman, & Chhillar, R. S. (2023). Optimized stacking ensemble for early-stage diabetes mellitus prediction. International Journal of Electrical and Computer Engineering, 13(6).

Aman, & Chhillar, R. S. (2024). A stacking-based hybrid model with random forest as meta-learner for diabetes mellitus prediction. International Journal of Machine Learning, 14(2), 54–58.

Aman, Chhillar, R. S., & Chhillar, U. (2023). Disease prediction in healthcare: An ensemble learning perspective.

Aman, Chhillar, R. S., & Chhillar, U. (2024). Machine learning in the battle against COVID-19: Predictive models and future directions. Future Computing Technologies for Sustainable Development (NCFCTSD-24).

Aman, Chhillar, R. S., & Chhillar, U. (2025). Machine learning and chronic kidney disease: Towards early prediction and diagnosis. Emerging Trends in Engineering, Commerce, Management and Hospitality Management in the Digital Age for a Sustainable Future.

Darolia, A., Chhillar, R. S., Alhussein, M., Dalal, S., Aurangzeb, K., & Lilhore, U. K. (2024). Enhanced cardiovascular disease prediction through self-improved Aquila optimized feature selection in quantum neural network and LSTM model. Frontiers in Medicine, 11, 1414637.

Aman, C. R. (2020). Disease predictive models for healthcare by using data mining techniques: State of the art. SSRG International Journal of Engineering Trends and Technology, 68(10). Available: https://www.researchgate.net/profile/Aman-Darolia/publication/345397957_Disease_Predictive_Models_for_Healthcare_by_using_Data_Mining_Techniques_State_of_the_Art/links/63b599fa03aad5368e64aa42/Disease-Predictive-Models-for-Healthcare-by-using-Data-Mining-Techniques-State-of-the-Art.pdf

Sutton, R. S., & Barto, A. G. (2018). Reinforcement learning: An introduction. MIT Press.

Silver, D., Huang, A., Maddison, C. J., et al. (2016). Mastering the game of Go with deep neural networks and tree search. Nature, 529(7587), 484–489.

Yu, C., Liu, J., Nemati, S., et al. (2019). Reinforcement learning in healthcare: A survey. ACM Computing Surveys, 52(5), 1–36.

Komorowski, M., Celi, L. A., Badawi, O., et al. (2018). The artificial intelligence clinician learns optimal treatment strategies for sepsis. Nature Medicine, 24(11), 1716–1720.

Published

2026-01-22

How to Cite

Sandhu, G., Dhillon, K., Menon, D., & Shah, T. (2026). Autonomous AI-Driven Clinical Decision System Using Reinforcement Learning and Real-Time Patient Feedback. International Journal of Unified Research & Development (IJURD), 2(1). https://doi.org/10.5281/ijurd.v2i1.29